Michael Mano - 02 Mar 2026 Form 4 Insider Report for Karyopharm Therapeutics Inc. (KPTI)

Role: EVP, CLO&Secretary
Signature: /s/ Nancy Smith as Attorney-in-Fact for Michael Mano
Issuer symbol: KPTI
Transactions as of: 02 Mar 2026
Net transactions value: -$33,178
Form type: 4
Filing time: 03 Mar 2026, 16:28:39 UTC
Previous filing: 03 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Mano Michael	EVP, CLO&Secretary	C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON	/s/ Nancy Smith as Attorney-in-Fact for Michael Mano	03 Mar 2026	0001837741

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	KPTI	Common Stock	Sale	$33,178	-3,526	-3.6%	$9.41	93,964	02 Mar 2026	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on May 16, 2022, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person.