Yvonne Greenstreet - Nov 26, 2025 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role
Chief Executive Officer, Director
Signature
By: Brett Budzinski, Attorney-in-Fact For: Yvonne Greenstreet
Stock symbol
ALNY
Transactions as of
Nov 26, 2025
Transactions value $
$777
Form type
4
Date filed
12/1/2025, 04:10 PM
Previous filing
Nov 14, 2025
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Greenstreet Yvonne Chief Executive Officer, Director 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE By: Brett Budzinski, Attorney-in-Fact For: Yvonne Greenstreet 2025-12-01 0001446125

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction ALNY Common Stock Options Exercise $100K +839 +1.28% $119.13 66.2K Nov 26, 2025 Direct
transaction ALNY Common Stock Options Exercise $200K +2.35K +3.55% $85.00 68.6K Nov 26, 2025 Direct
transaction ALNY Common Stock Options Exercise $100K +847 +1.23% $118.05 69.4K Nov 26, 2025 Direct
transaction ALNY Common Stock Options Exercise $99.9K +659 +0.95% $151.59 70.1K Nov 26, 2025 Direct
transaction ALNY Common Stock Tax liability -$499K -1.12K -1.6% $445.12 69K Nov 26, 2025 Direct
holding ALNY Common Stock 407 Nov 26, 2025 by Managed Account F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction ALNY Stock Option (right to buy) Options Exercise $0 -2.35K -100% $0.00 0 Nov 26, 2025 Common Stock 2.35K $85.00 Direct F2
transaction ALNY Stock Option (right to buy) Options Exercise $0 -847 -100% $0.00 0 Nov 26, 2025 Common Stock 847 $118.05 Direct F3
transaction ALNY Stock Option (right to buy) Options Exercise $0 -839 -100% $0.00 0 Nov 26, 2025 Common Stock 839 $119.13 Direct F4
transaction ALNY Stock Option (right to buy) Options Exercise $0 -659 -2.29% $0.00 28.1K Nov 26, 2025 Common Stock 659 $151.59 Direct F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program.
F2 This stock option was fully vested and exercisable as of February 28, 2023.
F3 This stock option was fully vested and exercisable as of February 26, 2024.
F4 This stock option was fully vested and exercisable as of December 1, 2021.
F5 This stock option was fully vested and exercisable as of February 24, 2025.