| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Greenstreet Yvonne | Chief Executive Officer, Director | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Yvonne Greenstreet | 14 Nov 2025 | 0001446125 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Options Exercise | $27,443 | +650 | +0.99% | $42.22 | 66,059 | 12 Nov 2025 | Direct | F1 |
| transaction | ALNY | Common Stock | Options Exercise | $1,786,950 | +15,000 | +23% | $119.13 | 81,059 | 12 Nov 2025 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | $318,578 | -711 | -0.88% | $448.07 | 80,348 | 12 Nov 2025 | Direct | F1, F2 |
| transaction | ALNY | Common Stock | Sale | $957,588 | -2,132 | -2.7% | $449.15 | 78,216 | 12 Nov 2025 | Direct | F1, F3 |
| transaction | ALNY | Common Stock | Sale | $203,927 | -453 | -0.58% | $450.17 | 77,763 | 12 Nov 2025 | Direct | F1, F4 |
| transaction | ALNY | Common Stock | Sale | $566,206 | -1,255 | -1.6% | $451.16 | 76,508 | 12 Nov 2025 | Direct | F1, F5 |
| transaction | ALNY | Common Stock | Sale | $547,440 | -1,210 | -1.6% | $452.43 | 75,298 | 12 Nov 2025 | Direct | F1, F6 |
| transaction | ALNY | Common Stock | Sale | $484,813 | -1,069 | -1.4% | $453.52 | 74,229 | 12 Nov 2025 | Direct | F1, F7 |
| transaction | ALNY | Common Stock | Sale | $891,486 | -1,960 | -2.6% | $454.84 | 72,269 | 12 Nov 2025 | Direct | F1, F8 |
| transaction | ALNY | Common Stock | Sale | $1,551,637 | -3,406 | -4.7% | $455.56 | 68,863 | 12 Nov 2025 | Direct | F1, F9 |
| transaction | ALNY | Common Stock | Sale | $1,105,069 | -2,420 | -3.5% | $456.64 | 66,443 | 12 Nov 2025 | Direct | F1, F10 |
| transaction | ALNY | Common Stock | Sale | $276,457 | -604 | -0.91% | $457.71 | 65,839 | 12 Nov 2025 | Direct | F1, F11 |
| transaction | ALNY | Common Stock | Sale | $197,121 | -430 | -0.65% | $458.42 | 65,409 | 12 Nov 2025 | Direct | F1, F12 |
| transaction | ALNY | Common Stock | Options Exercise | $1,191,300 | +10,000 | +15% | $119.13 | 75,409 | 13 Nov 2025 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | $292,815 | -654 | -0.87% | $447.73 | 74,755 | 13 Nov 2025 | Direct | F1, F13 |
| transaction | ALNY | Common Stock | Sale | $454,594 | -1,013 | -1.4% | $448.76 | 73,742 | 13 Nov 2025 | Direct | F1, F14 |
| transaction | ALNY | Common Stock | Sale | $664,680 | -1,477 | -2% | $450.02 | 72,265 | 13 Nov 2025 | Direct | F1, F15 |
| transaction | ALNY | Common Stock | Sale | $999,630 | -2,218 | -3.1% | $450.69 | 70,047 | 13 Nov 2025 | Direct | F1, F16 |
| transaction | ALNY | Common Stock | Sale | $769,202 | -1,702 | -2.4% | $451.94 | 68,345 | 13 Nov 2025 | Direct | F1, F17 |
| transaction | ALNY | Common Stock | Sale | $724,107 | -1,599 | -2.3% | $452.85 | 66,746 | 13 Nov 2025 | Direct | F1, F18 |
| transaction | ALNY | Common Stock | Sale | $399,965 | -881 | -1.3% | $453.99 | 65,865 | 13 Nov 2025 | Direct | F1, F19 |
| transaction | ALNY | Common Stock | Sale | $88,665 | -195 | -0.3% | $454.69 | 65,670 | 13 Nov 2025 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | $119,024 | -261 | -0.4% | $456.03 | 65,409 | 13 Nov 2025 | Direct | F1 |
| holding | ALNY | Common Stock | 407 | 12 Nov 2025 | by Managed Account | F20 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Performance Stock Option 2016 (right to buy) | Options Exercise | $0 | -650 | -100% | $0.000000 | 0 | 12 Nov 2025 | Common Stock | 650 | $42.22 | Direct | F1, F21 |
| transaction | ALNY | Performance Stock Option 2017 (right to buy) | Options Exercise | $0 | -15,000 | -60% | $0.000000 | 10,000 | 12 Nov 2025 | Common Stock | 15,000 | $119.13 | Direct | F1, F22 |
| transaction | ALNY | Performance Stock Option 2017 (right to buy) | Options Exercise | $0 | -10,000 | -100% | $0.000000 | 0 | 13 Nov 2025 | Common Stock | 10,000 | $119.13 | Direct | F1, F22 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on August 13, 2025. |
| F2 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $447.67 to $448.67. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F3 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $448.69 to $449.69. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F4 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $449.72 to $450.64. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F5 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $450.75 to $451.55. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F6 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.95 to $452.89. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F7 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $453.14 to $454.11. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F8 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $454.16 to $455.16. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F9 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $455.17 to $456.15. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F10 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $456.22 to $457.19. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F11 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $457.24 to $458.06. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F12 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $458.37 to $458.56. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F13 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $447.30 to $448.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F14 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $448.38 to $449.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F15 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $449.50 to $450.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F16 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $450.56 to $451.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F17 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.60 to $452.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F18 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $452.51 to $453.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F19 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $453.55 to $454.46. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F20 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |
| F21 | This stock option was fully vested and exercisable as of August 6, 2019. |
| F22 | This stock option was fully vested and exercisable as of February 11, 2021. |