Christopher U. Missling - 20 Aug 2025 Form 4 Insider Report for ANAVEX LIFE SCIENCES CORP. (AVXL)

Role: President and CEO, Director
Signature: /s/Christopher Missling
Issuer symbol: AVXL
Transactions as of: 20 Aug 2025
Net transactions value: $0
Form type: 4
Filing time: 22 Aug 2025, 17:30:05 UTC
Previous filing: 30 Apr 2025
Next filing: 12 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
MISSLING CHRISTOPHER U	President and CEO, Director	630 5TH AVENUE, 20TH FLOOR, NEW YORK	/s/Christopher Missling	22 Aug 2025	0001196573

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	AVXL	Stock Option (Right to Buy)	Award	$0	+125,000		$0.000000	125,000	20 Aug 2025	Common Stock	125,000	$8.58	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	On March 31, 2025, the reporting person was granted an option to purchase 500,000 shares of common stock. The option vests in four equal tranches based on four performance milestones, one of which was Publication of preclinical blarcamesine prevention AD data. The performance criteria for this milestone was met, resulting in vesting of the option as to 125,000 shares.