Corwin Dale Hooks - 09 Mar 2026 Form 4 Insider Report for SPRUCE BIOSCIENCES, INC. (SPRB)

Role: Chief Commercial Officer
Signature: /s/ Samir Gharib, Attorney-in-Fact
Issuer symbol: SPRB
Transactions as of: 09 Mar 2026
Net transactions value: $0
Form type: 4
Filing time: 09 Mar 2026, 16:08:18 UTC
Previous filing: 03 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Hooks Corwin Dale	Chief Commercial Officer	C/O SPRUCE BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 740, SOUTH SAN FRANCISCO	/s/ Samir Gharib, Attorney-in-Fact	09 Mar 2026	0001665347

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SPRB	Restricted Stock Units	Award		+11,000		$0.000000^*	11,000	09 Mar 2026	Common Stock	11,000	$0.000000	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock.
F2	25% of the total number of restricted stock units ("RSUs") will vest on March 15, 2027. 25% of the total number of RSUs will vest on each of March 15, 2028, March 15, 2029 and March 15, 2030, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan) as of each such vesting date.