John Oyler - Jun 23, 2025 Form 4 Insider Report for BeOne Medicines Ltd. (ONC)

Role: Chief Executive Officer, Director
Signature: /s/ Qing Nian, as Attorney-in-Fact
Stock symbol: ONC
Transactions as of: Jun 23, 2025
Transactions value $: -$830,360
Form type: 4
Date filed: 6/25/2025, 05:06 PM
Previous filing: Jun 18, 2025
Next filing: Jul 11, 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
OYLER JOHN	Chief Executive Officer, Director	C/O BEONE MEDICINES I GMBH, AESCHENGRABEN 27, 21ST FLOOR, BASEL, SWITZERLAND	/s/ Qing Nian, as Attorney-in-Fact	2025-06-25	0001042047

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ONC	American Depositary Shares	Sale	-$804K	-3.07K	-96.85%	$261.57	100	Jun 23, 2025	Direct	F6, F7
transaction	ONC	American Depositary Shares	Sale	-$26.3K	-100	-100%	$262.90	0	Jun 23, 2025	Direct	F6, F7
holding	ONC	Ordinary Shares						8.17M	Jun 23, 2025	Direct
holding	ONC	Ordinary Shares						482K	Jun 23, 2025	See Footnote	F1
holding	ONC	Ordinary Shares						7.72M	Jun 23, 2025	See Footnote	F2
holding	ONC	Ordinary Shares						28.2M	Jun 23, 2025	See Footnote	F3
holding	ONC	Ordinary Shares						9.55M	Jun 23, 2025	See Footnote	F4
holding	ONC	Ordinary Shares						102K	Jun 23, 2025	See Footnote	F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.
F2	These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
F3	These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
F4	These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.
F5	These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.
F6	Each American Depositary Share represents 13 Ordinary Shares
F7	The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 22, 2022, subject to continued service. Unvested securities are subject to accelerated vesting upon change of control or certain termination events.