| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Romano Steven J. | EVP and Chief R&D Officer | C/O SILENCE THERAPEUTICS PLC, 12 HAMMERSMITH GROVE, LONDON, UNITED KINGDOM | /s/ Rhonda Hellums, Attorney-in-Fact | 06 Jan 2026 | 0001639860 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SLN | Employee Share Option (Right to Buy) | Award | $0 | +300,000 | $0.000000 | 300,000 | 02 Jan 2026 | Ordinary Shares | 300,000 | $2.05 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2027 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date. |