JAMES EDGEMOND - 10 Nov 2025 Form 4 Insider Report for UNITED THERAPEUTICS Corp (UTHR)

Role: CFO AND TREASURER
Signature: /s/ John S. Hess, Jr. under Power of Attorney
Issuer symbol: UTHR
Transactions as of: 10 Nov 2025
Net transactions value: -$6,426,853
Form type: 4
Filing time: 12 Nov 2025, 17:13:49 UTC
Previous filing: 05 Nov 2025
Next filing: 18 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
EDGEMOND JAMES	CFO AND TREASURER	C/O UNITED THERAPEUTICS CORPORATION, 1000 SPRING STREET, SILVER SPRING	/s/ John S. Hess, Jr. under Power of Attorney	12 Nov 2025	0001636178

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	UTHR	Common Stock	Options Exercise	$3,066,630	+21,000	+259%	$146.03	29,118	10 Nov 2025	Direct	F1
transaction	UTHR	Common Stock	Sale	$469,727	-1,052	-3.6%	$446.51	28,066	10 Nov 2025	Direct	F1, F2
transaction	UTHR	Common Stock	Sale	$688,655	-1,539	-5.5%	$447.47	26,527	10 Nov 2025	Direct	F1, F3
transaction	UTHR	Common Stock	Sale	$1,504,595	-3,356	-13%	$448.33	23,171	10 Nov 2025	Direct	F1
transaction	UTHR	Common Stock	Sale	$293,197	-653	-2.8%	$449.00	22,518	10 Nov 2025	Direct	F1, F4
transaction	UTHR	Common Stock	Sale	$270,480	-600	-2.7%	$450.80	21,918	10 Nov 2025	Direct	F1, F5
transaction	UTHR	Common Stock	Sale	$481,240	-1,065	-4.9%	$451.87	20,853	10 Nov 2025	Direct	F1, F6
transaction	UTHR	Common Stock	Sale	$982,479	-2,170	-10%	$452.76	18,683	10 Nov 2025	Direct	F1, F7
transaction	UTHR	Common Stock	Sale	$2,102,517	-4,633	-25%	$453.81	14,050	10 Nov 2025	Direct	F1, F8
transaction	UTHR	Common Stock	Sale	$1,519,994	-3,342	-24%	$454.82	10,708	10 Nov 2025	Direct	F1, F9
transaction	UTHR	Common Stock	Sale	$1,180,598	-2,590	-24%	$455.83	8,118	10 Nov 2025	Direct	F1, F10

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	UTHR	Stock Option	Options Exercise	$0	-21,000	-67%	$0.000000	10,312	10 Nov 2025	Common Stock	21,000	$146.03	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id	Content
F1	This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on August 5, 2025.
F10	This transaction was executed in multiple trades at prices ranging from $455.35 to $456.27. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F2	This transaction was executed in multiple trades at prices ranging from $445.81 to $446.80. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F3	This transaction was executed in multiple trades at prices ranging from $446.81 to $447.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F4	This transaction was executed in multiple trades at prices ranging from $448.82 to $449.59. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F5	This transaction was executed in multiple trades at prices ranging from $450.24 to $451.05. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F6	This transaction was executed in multiple trades at prices ranging from $451.31 to $452.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F7	This transaction was executed in multiple trades at prices ranging from $452.32 to $453.20. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F8	This transaction was executed in multiple trades at prices ranging from $453.34 to $454.33. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
F9	This transaction was executed in multiple trades at prices ranging from $454.35 to $455.34. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.