| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Madsen Julia | Sr. VP and GM, Life Sciences | 70 SIR JOHN ROGERSON'S QUAY, DUBLIN 2, IRELAND | /s/ John P. Ubbing, Authorized Representative under Power of Attorney | 25 Nov 2025 | 0001819129 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | STE | Ordinary Shares | Options Exercise | $328,040 | +2,872 | +27% | $114.22 | 13,582 | 21 Nov 2025 | Direct | F1 |
| transaction | STE | Ordinary Shares | Sale | $752,464 | -2,872 | -21% | $262.00 | 10,710 | 21 Nov 2025 | Direct | F1 |
| transaction | STE | Ordinary Shares | Options Exercise | $314,099 | +2,136 | +20% | $147.05 | 12,846 | 21 Nov 2025 | Direct | F1 |
| transaction | STE | Ordinary Shares | Sale | $559,632 | -2,136 | -17% | $262.00 | 10,710 | 21 Nov 2025 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | STE | Employee Stock Option (right to buy) | Options Exercise | $0 | -2,872 | -100% | $0.000000 | 0 | 21 Nov 2025 | Ordinary Shares | 2,872 | $114.22 | Direct | F2 |
| transaction | STE | Employee Stock Option (right to buy) | Options Exercise | $0 | -2,136 | -100% | $0.000000 | 0 | 21 Nov 2025 | Ordinary Shares | 2,136 | $147.05 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | As of November 21, 2025, 4,003 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 578 on June 1, 2026, 352 on June 2, 2026; 666 on June 3, 2026; 542 on June 4, 2026; 666 on June 3, 2027; 542 on June 4, 2027 and 666 on June 5, 2028. |
| F2 | This option is fully vested. |