Zelanna Goldberg - Jun 1, 2021 Form 4 Insider Report for ALPINE IMMUNE SCIENCES, INC. (ALPN)

Role: Chief Medical Officer
Signature: /s/ James Paul Rickey, attorney-in-fact
Stock symbol: ALPN
Transactions as of: Jun 1, 2021
Transactions value $: $0
Form type: 4
Date filed: 6/2/2021, 06:16 PM

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ALPN	Stock Option (Right to buy)	Award	$0	+160K		$0.00	160K	Jun 1, 2021	Common Stock	160K	$10.29	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	1/4th of the shares subject to the option shall vest and become exercisable on 6/1/2022 (the "Vesting Commencement Date") and 1/48th of the shares subject to the option shall vest monthly thereafter on thesame day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), subject to the Reporting Person continuing to be a Service Provider through eachsuch date.

Content

1/4th of the shares subject to the option shall vest and become exercisable on 6/1/2022 (the "Vesting Commencement Date") and 1/48th of the shares subject to the option shall vest monthly thereafter on thesame day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), subject to the Reporting Person continuing to be a Service Provider through eachsuch date.