EcoR1 Capital, LLC - Jun 18, 2021 Form 4 Insider Report for PROTHENA CORP PUBLIC LTD CO (PRTA)

Role: 10%+ Owner
Signature: Oleg Nodelman, Manager of EcoR1 Capital, LLC
Stock symbol: PRTA
Transactions as of: Jun 18, 2021
Transactions value $: $7,500,000
Form type: 4
Date filed: 6/22/2021, 05:05 PM
Next filing: Sep 22, 2021

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PRTA	Ordinary Shares	Exercise of in-the-money or at-the-money derivative security	$7.5M	+250K	+2.27%	$30.00	11.3M	Jun 18, 2021	See Note 1	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PRTA	Call Option (Right to Purchase)	Exercise of in-the-money or at-the-money derivative security	$0	-2.5K	-100%	$0.00^*	0	Jun 18, 2021	Ordinary Shares	250K	$30.00	See Note 1	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.
F2	On June 18, 2021, the Filers exercised 2,500 call options to acquire 250,000 Ordinary Shares. Qualified Fund exercised 2,099 of those call options to acquire 209,900 Ordinary Shares. After this transaction, Qualified Fund owned 9,485,116 Ordinary Shares.

Content

The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 3 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

On June 18, 2021, the Filers exercised 2,500 call options to acquire 250,000 Ordinary Shares. Qualified Fund exercised 2,099 of those call options to acquire 209,900 Ordinary Shares. After this transaction, Qualified Fund owned 9,485,116 Ordinary Shares.