Karen M. Anderson - 16 Mar 2026 Form 4 Insider Report for Centessa Pharmaceuticals plc (CNTA)

Role
Chief People Officer
Signature
/s/ Raphael Deferiere, attorney-in-fact
Issuer symbol
CNTA
Transactions as of
16 Mar 2026
Net transactions value
-$2,109,180
Form type
4
Filing time
18 Mar 2026, 18:43:34 UTC
Previous filing
16 Mar 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Anderson Karen M. Chief People Officer C/O CENTESSA PHARMACEUTICALS PLC, 3RD FL., 1 ASHLEY RD, ALTRINCHAM, CHESHIRE, UNITED KINGDOM /s/ Raphael Deferiere, attorney-in-fact 18 Mar 2026 0001762176

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction CNTA Ordinary Shares Options Exercise +64,768 +104% $4.01* 126,853 16 Mar 2026 Direct F1
transaction CNTA Ordinary Shares Sale $1,826,969 -64,768 -51% $28.21 62,085 16 Mar 2026 Direct F1, F2, F3
transaction CNTA Ordinary Shares Options Exercise +10,043 +16% $4.01* 72,128 17 Mar 2026 Direct F1
transaction CNTA Ordinary Shares Sale $282,210 -10,043 -14% $28.10 62,085 17 Mar 2026 Direct F1, F2, F4

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction CNTA Share Option (right to buy) Options Exercise -64,768 -43% $0.000000* 85,043 16 Mar 2026 Ordinary Shares 64,768 $4.01 Direct F1, F5
transaction CNTA Share Option (right to buy) Options Exercise -10,043 -12% $0.000000* 75,000 17 Mar 2026 Ordinary Shares 10,043 $4.01 Direct F1, F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.
F2 The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025.
F3 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.99 to $28.41, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F4 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.99 to $28.21, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F5 25% of the shares subject to such option shall vest and become exercisable on December 1, 2023 and the remaining 75% of the shares subject to such option shall vest and become exercisable in 36 monthly installments on the first day of each month thereafter.