Mario Alberto Accardi - 01 Nov 2025 Form 4 Insider Report for Centessa Pharmaceuticals plc (CNTA)

Role: President, Orexin Program
Signature: /s/ Raphael Deferiere, attorney-in-fact
Issuer symbol: CNTA
Transactions as of: 01 Nov 2025
Net transactions value: -$14,766
Form type: 4
Filing time: 03 Nov 2025, 16:14:14 UTC
Previous filing: 27 Oct 2025
Next filing: 08 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Accardi Mario Alberto	President, Orexin Program	C/O CENTESSA PHARMACEUTICALS PLC, 3RD FL., 1 ASHLEY RD, ALTRINCHAM, CHESHIRE, UNITED KINGDOM	/s/ Raphael Deferiere, attorney-in-fact	03 Nov 2025	0002074392

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CNTA	Ordinary Shares	Tax liability	$14,766	-593	-0.31%	$24.90	193,801	01 Nov 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.
F2	Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted share units.