| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Hoppenot Herve | Director | C/O BICYCLE THERAPEUTICS PLC, BLOCKS A & B, PORTWAY BUILDING, CAMBRIDGE, UNITED KINGDOM | /s/ Travis Thompson, Attorney-in-Fact | 10 Sep 2025 | 0001596492 |
No securities are beneficially owned.