| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Ross Iain | Interim PEO, Director | C/O SILENCE THERAPEUTICS PLC, 12 HAMMERSMITH GROVE, LONDON, UNITED KINGDOM | /s/ Rhonda Hellums, Attorney-in-Fact | 22 Dec 2025 | 0001307218 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SLN | Employee Share Option (Right to Buy) | Award | $0 | +900,000 | $0.000000 | 900,000 | 18 Dec 2025 | Ordinary Shares | 900,000 | $2.08 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | This option shall vest in equal monthly installments over a one-year period measured from one month following December 18, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date. |