DENNIS MULROY - 06 Jan 2026 Form 4 Insider Report for ANAPTYSBIO, INC (ANAB)

Role: CHIEF FINANCIAL OFFICER
Signature: /s/ Eric Loumeau, Attorney-in-Fact
Issuer symbol: ANAB
Transactions as of: 06 Jan 2026
Net transactions value: -$86,070
Form type: 4
Filing time: 08 Jan 2026, 16:08:58 UTC
Previous filing: 06 Jan 2026
Next filing: 09 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
MULROY DENNIS	CHIEF FINANCIAL OFFICER	C/O ANAPTYSBIO, INC., 10770 WATERIDGE CIRCLE, SUITE 210, SAN DIEGO	/s/ Eric Loumeau, Attorney-in-Fact	08 Jan 2026	0001276840

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ANAB	Common Stock	Options Exercise		+5,245	+37%		19,575	06 Jan 2026	Direct	F1
transaction	ANAB	Common Stock	Sale	$86,070	-1,908	-9.7%	$45.11	17,667	07 Jan 2026	Direct	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ANAB	Restricted Stock Unit	Options Exercise	$0	-5,245	-50%	$0.000000	5,245	06 Jan 2026	Common Stock	5,245		Direct	F1, F3
transaction	ANAB	Restricted Stock Unit	Award	$0	+21,400		$0.000000	21,400	06 Jan 2026	Common Stock	21,400		Direct	F1, F4
transaction	ANAB	Stock Option (right to buy)	Award	$0	+29,000		$0.000000	29,000	06 Jan 2026	Common Stock	29,000	$43.91	Direct	F5

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration.
F2	The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person.
F3	The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2024 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.
F4	The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2027 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.
F5	The stock option vests as to 25% of the total shares on January 6, 2027, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.