| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| AKKARAJU SRINIVAS | Director | 628 MIDDLEFIELD ROAD, PALO ALTO | /s/ Srinivas Akkaraju | 16 Dec 2025 | 0001253170 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SRRK | Common Stock | Purchase | $503,011 | +12,796 | +2.6% | $39.31 | 513,235 | 07 Oct 2025 | By Samsara Opportunity Fund, L.P. | F1, F2 |
| transaction | SRRK | Common Stock | Purchase | $498,232 | +12,400 | +2.4% | $40.18 | 525,635 | 07 Oct 2025 | By Samsara Opportunity Fund, L.P. | F2, F3 |
| transaction | SRRK | Common Stock | Purchase | $180,391 | +4,403 | +0.84% | $40.97 | 530,038 | 07 Oct 2025 | By Samsara Opportunity Fund, L.P. | F2, F4 |
| transaction | SRRK | Common Stock | Exercise of in-the-money or at-the-money derivative security | $7,826,309 | +1,064,804 | +20% | $7.35 | 6,367,614 | 12 Dec 2025 | By Samsara BioCapital, L.P. | F5 |
| holding | SRRK | Common Stock | 21,132 | 07 Oct 2025 | Direct |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SRRK | Warrants to Purchase Common Stock | Exercise of in-the-money or at-the-money derivative security | $0 | -1,064,804 | -100% | $0.000000 | 0 | 12 Dec 2025 | Common Stock | 1,064,804 | $7.35 | By Samsara BioCapital LP | F5 |
| Id | Content |
|---|---|
| F1 | The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $38.85 to $39.849 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. |
| F2 | Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the securities held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein. |
| F3 | The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $39.8512 to $40.85 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. |
| F4 | The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $40.87 to $41.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. |
| F5 | Securities are directly held by Samsara BioCapital LP ("Samsara LP"). Samsara BioCapital GP, LLC ("Samsara LLC") is the general partner of Samsara LP and may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person has voting and investment power over the securities held by Samsara LP and, accordingly, may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein. |