| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| LEIDEN JEFFREY M | Executive Chairman, Director | C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON | /s/ Christiana Stevenson, Attorney-in-Fact | 26 Feb 2026 | 0001242825 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VRTX | Common Stock | Tax liability | $1,720,685 | -3,547 | -9.3% | $485.11 | 34,797 | 24 Feb 2026 | Direct | |
| holding | VRTX | Common Stock | 440 | 24 Feb 2026 | 401(k) |