| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Director, 10%+ Owner | 200 BERKELEY STREET 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. | 17 Oct 2025 | 0001346824 |
| RA Capital Healthcare Fund LP | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Healthcare GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. | 17 Oct 2025 | 0001315082 |
| RA Capital Nexus Fund, L.P. | Director | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC the General Partner of RA Capital Nexus Fund, L.P. | 17 Oct 2025 | 0001780117 |
| Kolchinsky Peter | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, individually | 17 Oct 2025 | 0001384859 |
| Shah Rajeev M. | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Rajeev Shah, individually | 17 Oct 2025 | 0001619841 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | VOR | Common Stock | Sale | $1,304,454 | -42,699 | -2.3% | $30.55 | 1,848,336 | 15 Oct 2025 | See footnotes | F1, F2, F3, F4 |
| transaction | VOR | Common Stock | Sale | $256,131 | -8,384 | -9.2% | $30.55 | 82,882 | 15 Oct 2025 | See footnotes | F1, F2, F3, F5 |
| transaction | VOR | Common Stock | Sale | $7,294 | -234 | -0.01% | $31.17 | 1,848,102 | 15 Oct 2025 | See footnotes | F3, F4, F6 |
| transaction | VOR | Common Stock | Sale | $1,434 | -46 | -0.06% | $31.17 | 82,836 | 15 Oct 2025 | See footnotes | F3, F5, F6 |
| transaction | VOR | Common Stock | Sale | $3,255,722 | -111,041 | -6% | $29.32 | 1,737,061 | 16 Oct 2025 | See footnotes | F3, F4, F7 |
| transaction | VOR | Common Stock | Sale | $639,293 | -21,804 | -26% | $29.32 | 61,032 | 16 Oct 2025 | See footnotes | F3, F5, F7 |
| transaction | VOR | Common Stock | Sale | $480,477 | -15,826 | -0.91% | $30.36 | 1,721,235 | 16 Oct 2025 | See footnotes | F3, F4, F8 |
| transaction | VOR | Common Stock | Sale | $94,359 | -3,108 | -5.1% | $30.36 | 57,924 | 16 Oct 2025 | See footnotes | F3, F5, F8 |
| transaction | VOR | Common Stock | Sale | $627 | -20 | -0% | $31.35 | 1,721,215 | 16 Oct 2025 | See footnotes | F3, F4 |
| transaction | VOR | Common Stock | Sale | $125 | -4 | -0.01% | $31.35 | 57,920 | 16 Oct 2025 | See footnotes | F3, F5 |
| transaction | VOR | Common Stock | Sale | $5,084,177 | -174,594 | -10% | $29.12 | 1,546,621 | 17 Oct 2025 | See footnotes | F3, F4, F9 |
| transaction | VOR | Common Stock | Sale | $998,350 | -34,284 | -59% | $29.12 | 23,636 | 17 Oct 2025 | See footnotes | F3, F5, F9 |
| transaction | VOR | Common Stock | Sale | $931,352 | -30,758 | -2% | $30.28 | 1,515,863 | 17 Oct 2025 | See footnotes | F3, F4, F10 |
| transaction | VOR | Common Stock | Sale | $182,891 | -6,040 | -26% | $30.28 | 17,596 | 17 Oct 2025 | See footnotes | F3, F5, F10 |
| transaction | VOR | Common Stock | Sale | $393,421 | -12,691 | -0.84% | $31.00 | 1,503,172 | 17 Oct 2025 | See footnotes | F3, F4 |
| transaction | VOR | Common Stock | Sale | $77,252 | -2,492 | -14% | $31.00 | 15,104 | 17 Oct 2025 | See footnotes | F3, F5 |
| Id | Content |
|---|---|
| F1 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.15 to $31.14 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
| F2 | On September 18, 2025, the Issuer effected a 1-for-20 reverse stock split. The share counts herein reflect the reverse stock split. |
| F3 | RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein. |
| F4 | Held directly by the Fund. |
| F5 | Held directly by the Nexus Fund. |
| F6 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.17 to $31.20 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
| F7 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.00 to $29.695 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
| F8 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.00 to $30.80 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
| F9 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.85 to $29.70 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
| F10 | The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.00 to $30.65 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. |
Ms. Sarah Reed, General Counsel of the Adviser, serves on the Issuer's board of directors.