| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. | 30 Sep 2025 | 0001346824 |
| RA Capital Healthcare Fund LP | Director, 10%+ Owner | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. | 30 Sep 2025 | 0001315082 |
| RA Capital Nexus Fund II, L.P. | Director | 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund II GP, LLC, the General Partner of RA Capital Nexus Fund II, L.P. | 30 Sep 2025 | 0001825376 |
| Kolchinsky Peter | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Peter Kolchinsky, individually | 30 Sep 2025 | 0001384859 |
| Shah Rajeev M. | Director, 10%+ Owner | C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON | /s/ Rajeev Shah, individually | 30 Sep 2025 | 0001619841 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PEPG | Common Stock | Purchase | $30,000,000 | +9,375,000 | +102% | $3.20 | 18,554,273 | 26 Sep 2025 | See footnotes | F1, F2 |
| holding | PEPG | Common Stock | 1,302,600 | 26 Sep 2025 | See footnotes | F2, F3 | |||||
| holding | PEPG | Common Stock | 207,672 | 26 Sep 2025 | See footnotes | F2, F4 |
| Id | Content |
|---|---|
| F1 | These securities are held directly by RA Capital Healthcare Fund, L.P. (the "Fund"). |
| F2 | RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein. |
| F3 | These securities are held directly by the Nexus Fund II. |
| F4 | These securities are held directly by the Account. |
Joshua Resnick, a Partner of the Adviser, serves on the Issuer's board of directors.