MARC H. HEDRICK - 25 Feb 2026 Form 4 Insider Report for PLUS THERAPEUTICS, INC. (PSTV)

Role: Chief Executive Officer, Director
Signature: Andrew Sims, as attorney-in-fact
Issuer symbol: PSTV
Transactions as of: 25 Feb 2026
Net transactions value: $0
Form type: 4
Filing time: 27 Feb 2026, 16:07:51 UTC
Previous filing: 02 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
HEDRICK MARC H	Chief Executive Officer, Director	C/O PLUS THERAPEUTICS INC., 6420 LEVIT GREEN BOULEVARD, SUITE 310, HOUSTON	Andrew Sims, as attorney-in-fact	27 Feb 2026	0001203672

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PSTV	Restricted Stock Units	Award	$0	+2,419,582	+152%	$0.000000	4,016,388	25 Feb 2026	Common Stock	2,419,582	$0.000000	Direct	F1
transaction	PSTV	Stock Option (Right to Buy)	Award	$0	+2,419,582		$0.000000	2,419,582	25 Feb 2026	Common Stock	2,419,582	$0.2800	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs awarded vest ratably over twelve quarters in substantially equal 1/12th increments, commencing with 1/12th vesting on April 1, 2026 and the remainder vesting quarterly thereafter.
F2	The options vest over four years in substantially equal 1/48th increments on each monthly anniversary of the issuance and vest on a change of control in accordance with the Optionee's employment agreement.