Elizabeth Bhatt - 18 Feb 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role
President and COO
Signature
/s/ Mark A. Wilson, Attorney-in-Fact
Issuer symbol
SEPN
Transactions as of
18 Feb 2026
Net transactions value
-$88,620
Form type
4
Filing time
20 Feb 2026, 17:28:57 UTC
Previous filing
10 Feb 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Bhatt Elizabeth President and COO C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO /s/ Mark A. Wilson, Attorney-in-Fact 20 Feb 2026 0001748622

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction SEPN Common Stock Options Exercise $27,240 +4,000 +2.3% $6.81 178,209 18 Feb 2026 Direct
transaction SEPN Common Stock Sale $62,611 -2,200 -1.2% $28.46 176,009 18 Feb 2026 Direct F1, F2
transaction SEPN Common Stock Sale $53,250 -1,800 -1% $29.58 174,209 18 Feb 2026 Direct F1, F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction SEPN Stock Option (Right to Buy) Options Exercise $0 -4,000 -4.3% $0.000000 88,911 18 Feb 2026 Common Stock 92,911 $6.81 Direct F4
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.
F2 The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.09 to $29.07. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F3 The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.12 to $29.98. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F4 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.