| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Finer Jeffrey | Chief Executive Officer, Director | C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO | /s/ Mark A. Wilson, Attorney-in-Fact | 10 Feb 2026 | 0002040376 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SEPN | Stock Option (Right to Buy) | Award | $0 | +400,000 | $0.000000 | 400,000 | 06 Feb 2026 | Common Stock | 400,000 | $25.41 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date. |
Exhibit 24.2 - Substitute Power of Attorney