Mark A. Wilson - 06 Feb 2026 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role: Chief Legal Officer
Signature: /s/ Mark A. Wilson
Issuer symbol: SEPN
Transactions as of: 06 Feb 2026
Net transactions value: $0
Form type: 4
Filing time: 10 Feb 2026, 19:01:23 UTC
Previous filing: 15 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Wilson Mark Andrew	Chief Legal Officer	C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO	/s/ Mark A. Wilson	10 Feb 2026	0001808356

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SEPN	Stock Option (Right to Buy)	Award	$0	+165,000		$0.000000	165,000	06 Feb 2026	Common Stock	165,000	$25.41	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	25% of the shares underlying this option will vest on January 5, 2027, and the remaining 75% of the shares underlying this option will vest in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.