Lori Macomber - 03 Feb 2026 Form 4 Insider Report for Karyopharm Therapeutics Inc. (KPTI)

Role
EVP, CFO & Treasurer
Signature
/s/ Nancy Smith as Attorney-in-Fact for Lori Macomber
Issuer symbol
KPTI
Transactions as of
03 Feb 2026
Net transactions value
-$10,244
Form type
4
Filing time
04 Feb 2026, 16:11:52 UTC
Previous filing
03 Feb 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Macomber Lori EVP, CFO & Treasurer C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON /s/ Nancy Smith as Attorney-in-Fact for Lori Macomber 04 Feb 2026 0001968671

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction KPTI Common Stock Sale $10,244 -1,626 -1.9% $6.30 85,105 03 Feb 2026 Direct F1
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on December 19, 2024, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person.