Kristin Abate - 27 Jan 2026 Form 4 Insider Report for Karyopharm Therapeutics Inc. (KPTI)

Role: Chief Accounting Officer
Signature: /s/ Nancy Smith as Attorney-in-Fact for Kristin Abate
Issuer symbol: KPTI
Transactions as of: 27 Jan 2026
Net transactions value: -$352
Form type: 4
Filing time: 29 Jan 2026, 16:57:15 UTC
Previous filing: 22 Jan 2026
Next filing: 03 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Abate Kristin	Chief Accounting Officer	C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON	/s/ Nancy Smith as Attorney-in-Fact for Kristin Abate	29 Jan 2026	0002045943

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	KPTI	Common Stock	Award	$0	+92	+0.41%	$0.000000	22,672	27 Jan 2026	Direct	F1
transaction	KPTI	Common Stock	Sale	$352	-50	-0.22%	$7.03	22,622	28 Jan 2026	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents the number of shares of the issuer's common stock underlying performance-based restricted stock units ("PSUs") granted in February 2023 that have been earned based on the level of achievement of the revenue and total shareholder return milestones as certified by the issuer's Compensation Committee on January 27, 2026. Each earned PSU represents the contingent right to receive one share of the issuer's common stock upon vesting. The earned PSUs vested on January 27, 2026.
F2	This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on May 27, 2021, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of PSUs. The sale does not represent a discretionary trade by the reporting person.

Content

Represents the number of shares of the issuer's common stock underlying performance-based restricted stock units ("PSUs") granted in February 2023 that have been earned based on the level of achievement of the revenue and total shareholder return milestones as certified by the issuer's Compensation Committee on January 27, 2026. Each earned PSU represents the contingent right to receive one share of the issuer's common stock upon vesting. The earned PSUs vested on January 27, 2026.

This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on May 27, 2021, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of PSUs. The sale does not represent a discretionary trade by the reporting person.