Andrew John Hugh MacIntyre Sims - 01 Jan 2026 Form 4 Insider Report for PLUS THERAPEUTICS, INC. (PSTV)

Role: Chief Financial Officer
Signature: /s/ Andrew Sims
Issuer symbol: PSTV
Transactions as of: 01 Jan 2026
Net transactions value: $0
Form type: 4
Filing time: 02 Jan 2026, 16:30:04 UTC
Previous filing: 05 Nov 2025
Next filing: 27 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Sims Andrew John Hugh MacIntyre	Chief Financial Officer	C/O PLUS THERAPEUTICS INC., 6420 LEVIT GREEN BOULEVARD, SUITE 310, HOUSTON	/s/ Andrew Sims	02 Jan 2026	0001802687

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PSTV	Common Stock	Options Exercise	$0	+38,323	+56%	$0.000000	106,461	01 Jan 2026	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PSTV	Restricted Stock Units	Options Exercise	$0	-38,323	-9.1%	$0.000000	383,232	01 Jan 2026	Common Stock	38,323	$0.000000	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the issuer's Common Stock.
F2	Represents the vesting of an RSU grant which occurs in twelve substantially equal quarterly installments beginning on October 1, 2025.