PERCEPTIVE ADVISORS LLC - 31 Dec 2025 Form 4 Insider Report for MeiraGTx Holdings plc (MGTX)

Role: Director, 10%+ Owner
Signature: /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member
Issuer symbol: MGTX
Transactions as of: 31 Dec 2025
Net transactions value: -$18,193,000
Form type: 4
Filing time: 02 Jan 2026, 16:15:45 UTC
Previous filing: 23 Dec 2025
Next filing: 11 Mar 2026
SEC: View on sec.gov

Reporting Owners (3)

Name	Relationship	Address	Signature	Signature date	CIK
PERCEPTIVE ADVISORS LLC	Director, 10%+ Owner	51 ASTOR PLACE, 10TH FLOOR, NEW YORK	/s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member	02 Jan 2026	0001224962
EDELMAN JOSEPH	Director, 10%+ Owner	51 ASTOR PLACE, 10TH FLOOR, NEW YORK	/s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member	02 Jan 2026	0001164426
PERCEPTIVE LIFE SCIENCES MASTER FUND LTD	Director, 10%+ Owner	51 ASTOR PLACE, 10TH FLOOR, NEW YORK	/s/ Joseph Edelman	02 Jan 2026	0001249675

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	MGTX	Ordinary Shares	Disposed to Issuer	$18,193,000	-2,300,000	-18%	$7.91	10,231,103	31 Dec 2025	See Footnote	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

Content

The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.