| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Kulkarni Samarth | Chief Executive Officer, Director | C/O CRISPR THERAPEUTICS, 105 WEST FIRST STREET, BOSTON | /s/Samarth Kulkarni | 22 Dec 2025 | 0001682019 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | CRSP | Common Shares | Gift | $0 | -30,000 | -12% | $0.000000 | 224,201 | 18 Dec 2025 | Direct | |
| holding | CRSP | Common Shares | 85,622 | 18 Dec 2025 | The Kulkarni 2023 GRAT |