Et al Phillip Frost MD - 18 Nov 2025 Form 4 Insider Report for OPKO HEALTH, INC. (OPK)

Role: CEO & Chairman, Director, 10%+ Owner
Signature: Phillip Frost, M.D., Individually and as Trustee
Issuer symbol: OPK
Transactions as of: 18 Nov 2025
Net transactions value: +$737,748
Form type: 4
Filing time: 18 Nov 2025, 17:18:12 UTC
Previous filing: 31 Oct 2025
Next filing: 19 Nov 2025
SEC: View on sec.gov

Reporting Owners (2)

Name	Relationship	Address	Signature	Signature date	CIK
FROST PHILLIP MD ET AL	CEO & Chairman, Director, 10%+ Owner	OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI	Phillip Frost, M.D., Individually and as Trustee	18 Nov 2025	0000898860
Frost Gamma Investments Trust	10%+ Owner	OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI	Phillip Frost, M.D., Individually and as Trustee	18 Nov 2025	0001380896

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	OPK	Common Stock	Purchase	$510	+410	+0%	$1.24	214,386,858	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$61,988	+49,590	+0.02%	$1.25	214,436,448	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$83,627	+66,635	+0.03%	$1.26	214,503,083	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Award	$58,842	+46,700	+0.02%	$1.26	214,549,783	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$18,975	+15,000	+0.01%	$1.26	214,564,783	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$2,250	+1,772	+0%	$1.27	214,566,555	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$271,075	+212,608	+0.1%	$1.28	214,779,163	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$89,252	+69,728	+0.03%	$1.28	214,848,891	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$550	+428	+0%	$1.28	214,849,319	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$107,369	+83,556	+0.04%	$1.28	214,932,875	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$1.29	+1	+0%	$1.29	214,932,876	18 Nov 2025	See Footnote	F1
transaction	OPK	Common Stock	Purchase	$43,308	+33,572	+0.02%	$1.29	214,966,448	18 Nov 2025	See Footnote	F1
holding	OPK	Common Stock						3,568,951	18 Nov 2025	Direct
holding	OPK	Common Stock						30,127,177	18 Nov 2025	See Footnote	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
F2	These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Content

The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.