| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| FROST PHILLIP MD ET AL | CEO & Chairman, Director, 10%+ Owner | OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI | Phillip Frost, M.D., Individually and as Trustee | 31 Oct 2025 | 0000898860 |
| Frost Gamma Investments Trust | 10%+ Owner | OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI | Phillip Frost, M.D., Individually and as Trustee | 31 Oct 2025 | 0001380896 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | OPK | Common Stock | Purchase | $213,435 | +150,000 | +0.07% | $1.42 | 214,386,448 | 31 Oct 2025 | See Footnote | F1, F2 |
| holding | OPK | Common Stock | 3,568,951 | 31 Oct 2025 | Direct | ||||||
| holding | OPK | Common Stock | 30,127,177 | 31 Oct 2025 | See Footnote | F3 |
| Id | Content |
|---|---|
| F1 | The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.415 to $1.4299, inclusive. The reporting person undertakes to provide to OPKO Health, Inc. (the "Company"), any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4. |
| F2 | The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. |
| F3 | These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. |