Validae Health, L.P. - 11 Nov 2025 Form 4 Insider Report for Metsera, Inc. (MTSR)

Role: 10%+ Owner
Signature: /s/ Christopher Cox, Managing Authorized Signatory of Validae
Issuer symbol: MTSR
Transactions as of: 11 Nov 2025
Net transactions value: $0
Form type: 4
Filing time: 13 Nov 2025, 21:05:03 UTC
Previous filing: 30 Jan 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Validae Health, L.P.	10%+ Owner	C/O POPULATION HEALTH PARTNERS, L.P., 1200 MORRIS TURNPIKE, SUITE 300, SHORT HILLS	/s/ Christopher Cox, Managing Authorized Signatory of Validae	13 Nov 2025	0002051634

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	MTSR	Common Stock	Other	$0	-12,767,462	-100%	$0.000000	0	11 Nov 2025	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Validae Health, L.P. is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may continue.

Explanation of Responses:

Id	Content
F1	Validae Health, L.P. ("Validae") distributed 99% of the shares of common stock of Metsera Inc. (the "Company") that it owned to Population Health Partners, L.P. ("PHP LP"), a partnership that owns 99% of its limited partnership interests, and 1% to Population Health Partners GP, LLC ("PHP GP LLC"), its sole general partner and owner of 1% of its limited partnership interests. PHP GP LLC is the sole general partner of Validae and PHP LP, and PHP GP LLC may be deemed to beneficially own the shares of common stock of the Company held by Validae and by PHP LP. Christopher Whitten Bernard, Christopher T. Cox and Clive A. Meanwell are members of PHP GP LLC and may be deemed to share the power to direct the disposition and vote of the shares of common stock of the Company held by the Validae, PHP GP LLC, and PHP LP.
F2	(Continued from footnote 1) Each of PHP GP LLC, Christopher Whitten Bernard, Christopher T. Cox and Clive A. Meanwell disclaims beneficial ownership of the reported securities except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that it is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Content

Validae Health, L.P. ("Validae") distributed 99% of the shares of common stock of Metsera Inc. (the "Company") that it owned to Population Health Partners, L.P. ("PHP LP"), a partnership that owns 99% of its limited partnership interests, and 1% to Population Health Partners GP, LLC ("PHP GP LLC"), its sole general partner and owner of 1% of its limited partnership interests. PHP GP LLC is the sole general partner of Validae and PHP LP, and PHP GP LLC may be deemed to beneficially own the shares of common stock of the Company held by Validae and by PHP LP. Christopher Whitten Bernard, Christopher T. Cox and Clive A. Meanwell are members of PHP GP LLC and may be deemed to share the power to direct the disposition and vote of the shares of common stock of the Company held by the Validae, PHP GP LLC, and PHP LP.

(Continued from footnote 1) Each of PHP GP LLC, Christopher Whitten Bernard, Christopher T. Cox and Clive A. Meanwell disclaims beneficial ownership of the reported securities except to the extent of its pecuniary interest therein, and this report shall not be deemed an admission that it is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.