| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Cheng Sohanya Roshan | EVP & Chief Commercial Officer | C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON | /s/ Nancy Smith as Attorney-in-Fact for Sohanya Cheng | 16 Oct 2025 | 0001865796 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | KPTI | Common Stock | Award | $0 | +43,650 | +122% | $0.000000 | 79,506 | 15 Oct 2025 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Represents the award of restricted stock units ("RSUs") pursuant to the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended. RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. The RSUs vest 100% on December 31, 2026. |