Samarth Kulkarni - 03 Oct 2025 Form 4 Insider Report for CRISPR Therapeutics AG (CRSP)

Role: Chief Executive Officer, Director
Signature: /s/ Elizabeth Ryland Waldinger, attorney-in-fact
Issuer symbol: CRSP
Transactions as of: 03 Oct 2025
Transactions value $: $0
Form type: 4
Filing time: 03 Oct 2025, 17:38:21 UTC
Previous filing: 19 Sep 2025
Next filing: 15 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Kulkarni Samarth	Chief Executive Officer, Director	C/O CRISPR THERAPEUTICS, 105 WEST FIRST STREET, BOSTON	/s/ Elizabeth Ryland Waldinger, attorney-in-fact	03 Oct 2025	0001682019

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	CRSP	Stock Option (Right to Buy)	Award	$0	+49.5K		$0.00	49.5K	03 Oct 2025	Common Shares	49.5K	$67.74	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This option was granted on October 3, 2025 with respect to 49,500 Common Shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of November 3, 2025.