Andrew John Hugh MacIntyre Sims - 01 Oct 2025 Form 4 Insider Report for PLUS THERAPEUTICS, INC. (PSTV)

Role: Chief Financial Officer
Signature: /s/ Andrew Sims
Issuer symbol: PSTV
Transactions as of: 01 Oct 2025
Net transactions value: $0
Form type: 4
Filing time: 03 Oct 2025, 16:30:06 UTC
Previous filing: 03 Oct 2025
Next filing: 05 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Sims Andrew John Hugh MacIntyre	Chief Financial Officer	C/O PLUS THERAPEUTICS INC., 4200 MARATHON BOULEVARD, SUITE 200, AUSTIN	/s/ Andrew Sims	03 Oct 2025	0001802687

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PSTV	Common Stock	Options Exercise	$0	+38,323	+390%	$0.000000	48,138	01 Oct 2025	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PSTV	Restricted Stock Units	Options Exercise	$0	-38,323	-8.3%	$0.000000	421,555	01 Oct 2025	Common Stock	38,323	$0.000000	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the issuer's Common Stock.
F2	Represents the vesting of an RSU grant which occurs in twelve substantially equal quarterly installments beginning on October 1, 2025.