STEPHEN J. HOFFMAN - 23 Oct 2025 Form 4 Insider Report for TALPHERA, INC. (TLPH)

Role: Director
Signature: /s/ Martha Adler, Attorney-in-Fact
Issuer symbol: TLPH
Transactions as of: 23 Oct 2025
Net transactions value: $0
Form type: 4
Filing time: 24 Oct 2025, 16:50:35 UTC
Previous filing: 24 Jun 2024
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
HOFFMAN STEPHEN J	Director	C/O TALPHERA, INC., 1850 GATEWAY DRIVE, SUITE 175, SAN MATEO	/s/ Martha Adler, Attorney-in-Fact	24 Oct 2025	0001190418

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	TLPH	Common Stock	Award	$0	+4,267	+93%	$0.000000	8,859	23 Oct 2025	Direct	F1, F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	TLPH	Stock Option (Right to Buy)	Award	$0	+25,600		$0.000000	25,600	23 Oct 2025	Common Stock	25,600	$1.14	Direct	F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.
F2	100% of the restricted stock units shall vest on the first anniversary of the grant date, subject to Reporting Person's continuous service to the Company.
F3	100% of the shares subject to the option shall vest on the one-year anniversary of the grant date, subject to the Reporting Person's continuous service to the Company.