| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| German Christopher Paul | Corporate Controller & CAO | 222 BERKELEY STREET, 12TH FLOOR, BOSTON | /s/ Stephen Vander Stoep, attorney-in-fact for Christopher Paul German | 06 Mar 2026 | 0001260835 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | RYTM | Common Stock | Options Exercise | +1,500 | +35% | $17.97* | 5,753 | 04 Mar 2026 | Direct | ||
| transaction | RYTM | Common Stock | Sale | $502,790 | -5,614 | -97% | $89.56 | 160 | 04 Mar 2026 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | RYTM | Stock Options (Right to Buy) | Options Exercise | -1,500 | -29% | $0.000000* | 3,731 | 04 Mar 2026 | Common Stock | 1,500 | $17.97 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | Includes 21 shares of Common Stock purchased pursuant to the Rhythm Pharmaceuticals, Inc. Employee Stock Purchase Plan. |
| F2 | The stock options were granted on April 4, 2023. The options vest and become exercisable as to 25% of the total shares on March 20, 2024 and, thereafter, as to the remaining 75% of the total shares in twelve equal quarterly installments of 6.25% beginning June 20, 2024 and ending March 20, 2027, subject to the Reporting Person's continued service on each such vesting date. |