Christopher Paul German - 01 Mar 2026 Form 4 Insider Report for RHYTHM PHARMACEUTICALS, INC. (RYTM)

Role: Corporate Controller & CAO
Signature: /s/ Stephen Vander Stoep, attorney-in-fact for Christopher Paul German
Issuer symbol: RYTM
Transactions as of: 01 Mar 2026
Net transactions value: -$32,469
Form type: 4
Filing time: 03 Mar 2026, 19:45:11 UTC
Previous filing: 13 Feb 2026
Next filing: 06 Mar 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
German Christopher Paul	Corporate Controller & CAO	222 BERKELEY STREET, 12TH FLOOR, BOSTON	/s/ Stephen Vander Stoep, attorney-in-fact for Christopher Paul German	03 Mar 2026	0001260835

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	RYTM	Common Stock	Options Exercise		+1,162	+34%		4,595	01 Mar 2026	Direct	F1
transaction	RYTM	Common Stock	Tax liability	$32,469	-342	-7.4%	$94.94	4,253	01 Mar 2026	Direct	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	RYTM	Restricted Stock Units	Options Exercise	$0	-1,162	-50%	$0.000000	1,162	01 Mar 2026	Common Stock	1,162		Direct	F1, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.
F2	These shares were withheld for payment of the withholding taxes upon the vesting of the restricted stock units reported herein.
F3	The restricted stock units vest as to 25% of the total shares on each of March 20, 2024, March 20, 2025, March 1, 2026 and March 1, 2027, subject to the Reporting Person's continued service on each such vesting date. The restricted stock units have no expiration date.