| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Williams Lewis T | Director | C/O PROTAGONIST THERAPEUTICS, INC., 7707 GATEWAY BLVD., SUITE 140, NEWARK | /s/ Matthew Gosling, Attorney-in-Fact for Lewis T. "Rusty" Williams | 18 Feb 2026 | 0001475714 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PTGX | Common Stock | Options Exercise | $195,120 | +18,000 | +230% | $10.84 | 25,825 | 17 Feb 2026 | Direct | |
| transaction | PTGX | Common Stock | Sale | $1,483,560 | -18,000 | -70% | $82.42 | 7,825 | 17 Feb 2026 | Direct | F1 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PTGX | Stock Option (right to buy) | Options Exercise | $0 | +18,000 | $0.000000 | 6,000 | 17 Feb 2026 | Common Stock | 18,000 | $10.84 | Direct | F2 |
| Id | Content |
|---|---|
| F1 | The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $81.47 to $83.12. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. |
| F2 | These stock options are fully vested. |