David R. Knox - 29 Sep 2025 Form 4 Insider Report for HYPERION DEFI, INC. (EYEN)

Role: Chief Financial Officer
Signature: /s/ David R. Knox
Issuer symbol: EYEN
Transactions as of: 29 Sep 2025
Net transactions value: $0
Form type: 4
Filing time: 01 Oct 2025, 16:02:32 UTC
Next filing: 05 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Knox David R.	Chief Financial Officer	C/O HYPERION DEFI, INC., 23461 SOUTH POINTE DRIVE, SUITE 390, LAGUNA HILLS	/s/ David R. Knox	01 Oct 2025	0002089491

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	HYPD	Common Stock, par value $0.0001	Award	$0	+100,000		$0.000000	100,000	29 Sep 2025	Direct	F1
transaction	HYPD	Common Stock, par value $0.0001	Award	$0	+200,000	+200%	$0.000000	300,000	29 Sep 2025	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents restricted stock units ("RSUs") that vest as follows: (1) 50,000 RSUs shall vest on March 29, 2026 and (2) 50,000 RSUs shall vest on September 29, 2026, subject to the Grantee's continued employment with the Company through each such vesting date.
F2	Represents restricted stock units ("RSUs") that vest as follows: (1) 100,000 RSUs shall vest upon the Company achieving a market capitalization of one hundred fifty million dollars ($150,000,000) and (2) 100,000 RSUs shall vest upon the Company achieving a market capitalization of five hundred million dollars ($500,000,000) (the "Market Cap Milestones"), with the Market Cap Milestones to be considered achieved if the applicable threshold is achieved on ten (10) trading days out of a rolling thirty (30) day period, subject to the Grantee's continued employment with the Company through each such vesting date.

Content

Represents restricted stock units ("RSUs") that vest as follows: (1) 50,000 RSUs shall vest on March 29, 2026 and (2) 50,000 RSUs shall vest on September 29, 2026, subject to the Grantee's continued employment with the Company through each such vesting date.

Represents restricted stock units ("RSUs") that vest as follows: (1) 100,000 RSUs shall vest upon the Company achieving a market capitalization of one hundred fifty million dollars ($150,000,000) and (2) 100,000 RSUs shall vest upon the Company achieving a market capitalization of five hundred million dollars ($500,000,000) (the "Market Cap Milestones"), with the Market Cap Milestones to be considered achieved if the applicable threshold is achieved on ten (10) trading days out of a rolling thirty (30) day period, subject to the Grantee's continued employment with the Company through each such vesting date.