| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Knox David R. | Chief Financial Officer | C/O HYPERION DEFI, INC., 23461 SOUTH POINTE DRIVE, SUITE 390, LAGUNA HILLS | /s/ David R. Knox | 05 Jan 2026 | 0002089491 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | HYPD | Common Stock, par value $0.0001 | Purchase | $100,340 | +27,950 | +9.3% | $3.59 | 327,950 | 31 Dec 2025 | Direct |