J. Russel Denton - 17 Jun 2025 Form 3 Insider Report for Caris Life Sciences, Inc.

Role: Senior Vice President, General Counsel, and Secretary. Exhibit 24 - Power of Attorney.
Signature: /s/ J. Russel Denton
Issuer symbol: CAI on Nasdaq
Transactions as of: 17 Jun 2025
Net transactions value: $0
Form type: 3
Filing time: 17 Jun 2025, 21:33:41 UTC
Previous filing: 23 Jun 2025
Next filing: 10 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Denton John Russel	Senior Vice President, General Counsel, and Secretary. Exhibit 24 - Power of Attorney.	C/O CARIS LIFE SCIENCES, INC., 750 W. JOHN CARPENTER FREEWAY, SUITE 800, IRVING	/s/ J. Russel Denton	17 Jun 2025	0002071923

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	CAI	Common Stock						16,770	17 Jun 2025	Direct
holding	CAI	Common Stock						5,000	17 Jun 2025	By Trust

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	CAI	Stock Option							17 Jun 2025	Common Stock	255,000	$18.60	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The stock option vested 60% at grant and will vest 20% on September 1, 2025 and 20% on September 1, 2026.

Remarks:

Senior Vice President, General Counsel, and Secretary. Exhibit 24 - Power of Attorney.