Nantahala Capital Management, LLC - 06 Jun 2025 Form 4 Insider Report for AYTU BIOPHARMA, INC (AYTU)

Role: 10%+ Owner
Signature: /s/ Taki Vasilakis, Chief Compliance Officer, Nantahala Capital Management, LLC
Issuer symbol: AYTU
Transactions as of: 06 Jun 2025
Net transactions value: +$5,999,600
Form type: 4
Filing time: 09 Jun 2025, 16:31:42 UTC
Previous filing: 17 Apr 2025
Next filing: 19 Dec 2025
SEC: View on sec.gov

Reporting Owners (3)

Name	Relationship	Address	Signature	Signature date	CIK
Nantahala Capital Management, LLC	10%+ Owner	130 MAIN ST. 2ND FLOOR, NEW CANAAN	/s/ Taki Vasilakis, Chief Compliance Officer, Nantahala Capital Management, LLC	09 Jun 2025	0001472322
Harkey Wilmot B.	10%+ Owner	C/O NANTAHALA CAPITAL MANAGEMENT, LLC, 130 MAIN ST. 2ND FLOOR, NEW CANAAN	/s/ Wilmot B. Harkey	09 Jun 2025	0001775952
Mack Daniel	10%+ Owner	C/O NANTAHALA CAPITAL MANAGEMENT, LLC, 130 MAIN ST. 2ND FLOOR, NEW CANAAN	/s/ Daniel Mack	09 Jun 2025	0001775831

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	AYTU	Prefunded Warrants	Purchase	$5,999,600	+4,000,000	+491%	$1.50	4,815,217	06 Jun 2025	Common Stock	4,000,000	$0.000100	See footnote	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Subject to certain limits on beneficial ownership, the Prefunded Warrants may be exercised to purchase Issuer Common Stock at an exercise price of $0.0001 per share. The Prefunded Warrants do not expire until exercised in full.
F2	Nantahala Capital Management, LLC ("NCM"), an investment adviser to certain private funds and managed accounts (the "NCM Investors") that hold the Aytu BioPharma, Inc ("Issuer") securities disclosed in this Form 4, may be deemed a beneficial owner of such securities. Each of Mr. Wilmot B Harkey and Mr. Daniel Mack may be deemed a beneficial owner of Issuer securities beneficially owned by NCM. Each of NCM, Mr. Harkey and Mr. Mack disclaims beneficial ownership of the Issuer's securities disclosed herein except to the extent of their respective pecuniary interests therein.

Content

Subject to certain limits on beneficial ownership, the Prefunded Warrants may be exercised to purchase Issuer Common Stock at an exercise price of $0.0001 per share. The Prefunded Warrants do not expire until exercised in full.

Nantahala Capital Management, LLC ("NCM"), an investment adviser to certain private funds and managed accounts (the "NCM Investors") that hold the Aytu BioPharma, Inc ("Issuer") securities disclosed in this Form 4, may be deemed a beneficial owner of such securities. Each of Mr. Wilmot B Harkey and Mr. Daniel Mack may be deemed a beneficial owner of Issuer securities beneficially owned by NCM. Each of NCM, Mr. Harkey and Mr. Mack disclaims beneficial ownership of the Issuer's securities disclosed herein except to the extent of their respective pecuniary interests therein.