RA CAPITAL MANAGEMENT, L.P. - 26 May 2021 Form 4 Insider Report for 89bio, Inc. (ETNB)

Role: Director, 10%+ Owner
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.
Issuer symbol: ETNB
Transactions as of: 26 May 2021
Net transactions value: +$3,857,063
Form type: 4
Filing time: 28 May 2021, 18:41:54 UTC
Next filing: 04 Jun 2021
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ETNB	Common Stock	Purchase	$872,237	+48,377	+1%	$18.03	4,784,591	26 May 2021	See Footnote	F1, F2, F7
transaction	ETNB	Common Stock	Purchase	$666,637	+35,535	+0.74%	$18.76	4,820,126	27 May 2021	See Footnote	F3, F4, F7
transaction	ETNB	Common Stock	Purchase	$2,318,189	+123,505	+2.6%	$18.77	4,943,631	28 May 2021	See Footnote	F5, F6, F7

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This transaction was executed in multiple trades at prices ranging from $17.78 to $18.37; the price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which these transactions, and all other transactions reported in this Form 4, were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.
F2	These securities include 4,449,227 shares held directly by RA Capital Healthcare Fund, L.P. (the "Fund") and 335,364 shares held by RA Capital Nexus Fund, L.P. ("the Nexus Fund").
F3	This transaction was executed in multiple trades at prices ranging from $ 18.21 to $ 18.82; the price reported above reflects the weighted average purchase price.
F4	These securities include 4,484,762 shares held directly by the Fund and 335,364 shares held by the Nexus Fund.
F5	This transaction was executed in multiple trades at prices ranging from $17.99 to $18.95; the price reported above reflects the weighted average purchase price.
F6	These securities include 4,608,267 shares held directly by the Fund and 335,364 shares held by the Nexus Fund.
F7	RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund and the Nexus Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.