Lisa M. DeFrancesco - 28 Feb 2026 Form 4 Insider Report for LEXICON PHARMACEUTICALS, INC. (LXRX)

Role
SVP, IR and Corp Comm
Signature
/s/ Lisa M. DeFrancesco
Issuer symbol
LXRX
Transactions as of
28 Feb 2026
Net transactions value
-$109,621
Form type
4
Filing time
03 Mar 2026, 07:18:00 UTC
Previous filing
17 Feb 2026
SEC
View on sec.gov

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
DeFrancesco Lisa SVP, IR and Corp Comm 2445 TECHNOLOGY FOREST BLVD, 11TH FLOOR, SPRING /s/ Lisa M. DeFrancesco 03 Mar 2026 0001846325

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction LXRX Common Stock Options Exercise +24,674 +158% 40,251 28 Feb 2026 Direct F1
transaction LXRX Common Stock Options Exercise +128,190 +318% 168,441 28 Feb 2026 Direct F1
transaction LXRX Common Stock Tax liability $109,621 -74,572 -44% $1.47 93,869 28 Feb 2026 Direct F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction LXRX Restricted Stock Units Options Exercise -24,674 -50% 24,673 28 Feb 2026 Common Stock 24,674 Direct F1, F3, F4
transaction LXRX Restricted Stock Units Options Exercise -128,190 -33% 256,380 28 Feb 2026 Common Stock 128,190 Direct F1, F4
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 Each restricted stock unit represents a contingent right to receive one share of common stock.
F2 Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.
F3 Each restricted stock unit represents a contingent right to receive one share of common stock.
F4 Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.