John Oyler - 11 Nov 2025 Form 4 Insider Report for BeOne Medicines Ltd. (ONC)

Role: Chief Executive Officer, Director
Signature: /s/ Qing Nian, as Attorney-in-Fact
Issuer symbol: ONC
Transactions as of: 11 Nov 2025
Net transactions value: $0
Form type: 4
Filing time: 13 Nov 2025, 17:06:47 UTC
Previous filing: 18 Sep 2025
Next filing: 17 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
OYLER JOHN	Chief Executive Officer, Director	C/O BEONE MEDICINES I GMBH, AESCHENGRABEN 27, 21ST FLOOR, BASEL, SWITZERLAND	/s/ Qing Nian, as Attorney-in-Fact	13 Nov 2025	0001042047

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ONC	Ordinary Shares	Gift	$0	-151,320	-2%	$0.000000	7,299,574	11 Nov 2025	Direct	F1
transaction	ONC	Ordinary Shares	Gift	$0	-858,533	-12%	$0.000000	6,441,041	12 Nov 2025	Direct	F1
holding	ONC	Ordinary Shares						481,533	11 Nov 2025	See Footnote	F2
holding	ONC	Ordinary Shares						7,722,480	11 Nov 2025	See Footnote	F3
holding	ONC	Ordinary Shares						28,204,115	11 Nov 2025	See Footnote	F4
holding	ONC	Ordinary Shares						9,545,000	11 Nov 2025	See Footnote	F5
holding	ONC	Ordinary Shares						102,188	11 Nov 2025	See Footnote	F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Bona fide gift of shares to a private foundation which is exempt from Section 16(b) of the Securities Exchange Act pursuant to Rule 16b-5.
F2	These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.
F3	These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
F4	These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
F5	These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.
F6	These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.