Mark Coleman - 08 Sep 2025 Form 4 Insider Report for Axsome Therapeutics, Inc. (AXSM)

Role: Director
Signature: /s/ Nick Pizzie, Attorney-in-Fact
Issuer symbol: AXSM
Transactions as of: 08 Sep 2025
Net transactions value: +$200,466
Form type: 4
Filing time: 09 Sep 2025, 20:11:58 UTC
Previous filing: 10 Jun 2025
Next filing: 10 Feb 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Coleman Mark	Director	C/O AXSOME THERAPEUTICS, INC., ONE WORLD TRADE CENTER, 29TH FLOOR, NEW YORK	/s/ Nick Pizzie, Attorney-in-Fact	09 Sep 2025	0001658379

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	AXSM	Common Stock	Purchase	$101,760	+800	+1.7%	$127.20	47,437	08 Sep 2025	Direct	F1
transaction	AXSM	Common Stock	Purchase	$36,535	+287	+0.61%	$127.30	47,724	08 Sep 2025	Direct	F1
transaction	AXSM	Common Stock	Purchase	$62,171	+488	+1%	$127.40	48,212	08 Sep 2025	Direct	F1
holding	AXSM	Common Stock						403,856	08 Sep 2025	See Footnote	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents the open market purchase of shares of the Issuer's common stock.
F2	Such shares are held by an entity, of which the reporting person has voting and dispositive power, and therefore, the reporting person is deemed to be the indirect beneficial owner of such shares.