Gil M. Labrucherie - 07 Aug 2025 Form 4 Insider Report for Septerna, Inc. (SEPN)

Role: Chief Financial Officer
Signature: /s/ Ran Xiao, Attorney-in-Fact
Issuer symbol: SEPN
Transactions as of: 07 Aug 2025
Net transactions value: $0
Form type: 4
Filing time: 11 Aug 2025, 19:06:48 UTC
Previous filing: 13 Jun 2025
Next filing: 21 Nov 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Labrucherie Gil M	Chief Financial Officer	C/O SEPTERNA, INC., 250 EAST GRAND AVENUE, SOUTH SAN FRANCISCO	/s/ Ran Xiao, Attorney-in-Fact	11 Aug 2025	0001394875

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SEPN	Stock Option (Right to Buy)	Award	$0	+37,500		$0.000000	37,500	07 Aug 2025	Common Stock	37,500	$11.70	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	6/48th of the shares subject to such option shall vest and become exercisable on February 1, 2026 and the remaining shares subject to the option shall vest in 42 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.