Quoc Le-Nguyen - 01 Aug 2025 Form 4 Insider Report for 89bio, Inc. (ETNB)

Role: Chief Technical Operations Officer
Signature: /s/ Ryan A. Murr, as attorney-in-fact for Quoc Le-Nguyen
Issuer symbol: ETNB
Transactions as of: 01 Aug 2025
Net transactions value: -$75,130
Form type: 4
Filing time: 05 Aug 2025, 20:14:06 UTC
Previous filing: 17 Jul 2025
Next filing: 30 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Le-Nguyen Quoc	Chief Technical Operations Officer	C/O 89BIO, INC., 655 MONTGOMERY STREET, SUITE 1500, SAN FRANCISCO	/s/ Ryan A. Murr, as attorney-in-fact for Quoc Le-Nguyen	05 Aug 2025	0001792062

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ETNB	Common Stock	Tax liability	$70,349	-7,680	-2.5%	$9.16	301,684	01 Aug 2025	Direct	F1
transaction	ETNB	Common Stock	Tax liability	$4,782	-522	-3.7%	$9.16	13,694	01 Aug 2025	By Spouse	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These shares were withheld from the vesting of restricted stock units to cover the estimated tax withholding obligation.

Remarks:

Chief Technical Operations Officer