| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Poulton Stuart | EVP, Chief Development Officer | C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE, NEWTON | /s/ Nancy Smith as Attorney-in-Fact for Stuart Poulton | 30 Jul 2025 | 0001942597 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | KPTI | Common Stock | Sale | $835 | -191 | -0.7% | $4.37 | 27,223 | 29 Jul 2025 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | This transaction was effected pursuant to a durable automatic sale instruction plan adopted by the reporting person on May 18, 2022, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units. The sale does not represent a discretionary trade by the reporting person. |